Skeletal FGFR1 signaling is necessary for regulation of serum phosphate level by FGF23 and normal life span.

ABSTRACT: Fibroblast growth factor (FGF) 23 produced by the bone is the principal hormone to regulate serum phosphate level. Serum FGF23 needs to be tightly regulated to maintain serum phosphate in a narrow range. Thus, we hypothesized that the bone has some phosphate-sensing mechanism to regulate the production of FGF23. Previously we showed that extracellular phosphate induces the phosphorylation of FGF receptor 1 (FGFR1) and FGFR1 signaling regulates the expression of Galnt3, whose product works to increase FGF23 production in vitro. In this study, we show the significance of FGFR1 in the regulated FGF23 production and serum phosphate level in vivo. We generated late-osteoblast/osteocyte-specific Fgfr1-knockout mice (Fgfr1 ^fl/fl ; Ocn

SUBMITTER: Takashi Y 

PROVIDER: S-EPMC8379418 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature