Novel magnetic silk fibroin scaffolds with delayed degradation for potential long-distance vascular repair.

ABSTRACT: Although with the good biological properties, silk fibroin (SF) is immensely restrained in long-distance vascular defect repair due to its relatively fast degradation and inferior mechanical properties. It is necessary to construct a multifunctional composite scaffold based on SF. In this study, a novel magnetic SF scaffold (MSFCs) was prepared by an improved infiltration method. Compared with SF scaffold (SFC), MSFCs were found to have better crystallinity, magnetocaloric properties, and mechanical strength, which was ascribed to the rational introduction of iron-based magnetic nanoparticles (MNPs). Moreover, in vivo and in vitro experiments demonstrated that the degradation of MSFCs was significantly extended. The mechanism of delayed degradation was correlated with the dua

SUBMITTER: Liu X 

PROVIDER: S-EPMC8379427 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature