Cerium oxide nanoparticles loaded nanofibrous membranes promote bone regeneration for periodontal tissue engineering.

ABSTRACT: Bone regeneration is a crucial part in the treatment of periodontal tissue regeneration, in which new attempts come out along with the development of nanomaterials. Herein, the effect of cerium oxide nanoparticles (CeO₂ NPs) on the cell behavior and function of human periodontal ligament stem cells (hPDLSCs) was investigated. Results of CCK-8 and cell cycle tests demonstrated that CeO₂ NPs not only had good biocompatibility, but also promoted cell proliferation. Furthermore, the levels of alkaline phosphatase activity, mineralized nodule formation and expressions of osteogenic genes and proteins demonstrated CeO₂ NPs could promote osteogenesis differentiation of hPDLSCs. Then we chose electrospinning to fabricate fibrous membranes containing CeO₂

SUBMITTER: Ren S 

PROVIDER: S-EPMC8379477 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature