Changes in Default-Mode Network Associated With Childhood Trauma in Schizophrenia.

ABSTRACT:

Background

There is considerable evidence of dysconnectivity within the default-mode network (DMN) in schizophrenia, as measured during resting-state functional MRI (rs-fMRI). History of childhood trauma (CT) is observed at a higher frequency in schizophrenia than in the general population, but its relationship to DMN functional connectivity has yet to be investigated.

Methods

CT history and rs-fMRI data were collected in 65 individuals with schizophrenia and 132 healthy controls. Seed-based functional connectivity between each of 4 a priori defined seeds of the DMN (medial prefrontal cortex, right and left lateral parietal lobes, and the posterior cingulate cortex) and all other voxels of the brain were compared across groups. Effects of CT on functional connectivity were e

SUBMITTER: Dauvermann MR 

PROVIDER: S-EPMC8379545 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature