Population Genetic Difference of Pharmacogenomic VIP Variants in the Tibetan Population.

ABSTRACT:

Background

Genetic variation influences drug reaction or adverse prognosis. The purpose of this research was to genotype very important pharmacogenetic (VIP) variants in the Tibetan population.

Methods and materials

Blood samples from 200 Tibetans were randomly collected and 59 VIP variants were genotyped, and then compared our data to 26 other populations in the 1000 project to further analyze and identify significant difference.

Results

The results showed that on comparing with most of the 26 populations from the 1000 project, rs4291 (ACE), rs1051296 (SLC19A1) and rs1065852 (CYP2D6) significantly differed in the Tibetan population. Furthermore, three significant loci were related to drug response. In addition, the allele frequency of Tibetans le

SUBMITTER: He C 

PROVIDER: S-EPMC8379641 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature