Endothelial BBSome is essential for vascular, metabolic, and retinal functions.

ABSTRACT:

Objectives

Endothelial cells that line the entire vascular system play a pivotal role in the control of various physiological processes, including metabolism. Additionally, endothelial dysfunction is associated with many pathological conditions, including obesity. Here, we assessed the role of the BBSome, a protein complex composed of eight Bardet-Biedl syndrome (BBS) proteins in endothelial cells.

Methods

We studied the effects of BBSome disruption in endothelial cells on vascular function, body weight, glucose homeostasis, and the liver and retina. For this, we generated mice with selective BBSome disruption in endothelial cells through Bbs1 gene deletion.

Results

We found that endothelial cell-specific BBSome disruption causes endothelial dysfunction, as indicated

SUBMITTER: Jiang J 

PROVIDER: S-EPMC8379702 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature