RIPK3 activation induces TRIM28 derepression in cancer cells and enhances the anti-tumor microenvironment.

ABSTRACT:

Background

Necroptosis is emerging as a new target for cancer immunotherapy as it is now recognized as a form of cell death that increases tumor immunogenicity, which would be especially helpful in treating immune-desert tumors. De novo synthesis of inflammatory proteins during necroptosis appears especially important in facilitating increased anti-tumor immune responses. While late-stage transcription mediated by NF-κB during cell death is believed to play a role in this process, it is otherwise unclear what cell signaling events initiate this transactivation of inflammatory genes.

Methods

We employed tandem-affinity purification linked to mass spectrometry (TAP-MS), in combination with the analysis of RNA-sequencing (RNA-Seq) datasets to identify the Tripartite Motif Prote

SUBMITTER: Park HH 

PROVIDER: S-EPMC8379748 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature