Discovery of metabolic biomarkers for gestational diabetes mellitus in a Chinese population.

ABSTRACT:

Background

Gestational diabetes mellitus (GDM), one of the most common pregnancy complications, can lead to morbidity and mortality in both the mother and the infant. Metabolomics has provided new insights into the pathology of GDM and systemic analysis of GDM with metabolites is required for providing more clues for GDM diagnosis and mechanism research. This study aims to reveal metabolic differences between normal pregnant women and GDM patients in the second- and third-trimester stages and to confirm the clinical relevance of these new findings.

Methods

Metabolites were quantitated with the serum samples of 200 healthy pregnant women and 200 GDM women in the second trimester, 199 normal controls, and 199 GDM patients in the third trimester. Both function and pathway analy

SUBMITTER: Lu W 

PROVIDER: S-EPMC8379750 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature