RVG-functionalized reduction sensitive micelles for the effective accumulation of doxorubicin in brain.

ABSTRACT:

Background

Glioblastoma is a lethal neoplasm with few effective therapy options. As a mainstay in the current treatment of glioma at present, chemotherapeutic agents usually show inadequate therapeutic efficiency due to their low blood brain barrier traversal and brain targeting, together with tumor multidrug resistance. Novel treatment strategies are thus urgently needed to improve chemotherapy outcomes.

Results

Here, we report that nanomedicines developed by functionalizing the neurotropic rabies virus-derived polypeptide, RVG, and loading reduction-sensitive nanomicelles (polymer and doxorubicin) enable a highly specific and efficacious drug accumulation in the brain. Interestingly, curcumin serves as the hydrophobic core of the polymer, while suppressing the major efflux

SUBMITTER: Xu J 

PROVIDER: S-EPMC8379803 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature