DNA methylome profiling reveals epigenetic regulation of lipoprotein-associated phospholipase A₂ in human vulnerable atherosclerotic plaque.

ABSTRACT:

Background

Atherosclerotic plaque vulnerability is a key feature of atheroprogression and precipitating acute cardiovascular events. Although the pivotal role of epigenetic regulation in atherosclerotic plaque destabilization is being recognized, the DNA methylation profile and its potential role in driving the progression and destabilization of atherosclerotic cardiovascular disease remains largely unknown. We conducted a genome-wide analysis to identify differentially methylated genes in vulnerable and non-vulnerable atherosclerotic lesions to understand more about pathogenesis.

Results

We compared genome-wide DNA methylation profiling between carotid artery plaques of patients with clinically symptomatic (recent stroke or transient ischemic attack) and asymptomatic diseas

SUBMITTER: Li J 

PROVIDER: S-EPMC8379831 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature