Longitudinal Study of Dark Adaptation as a Functional Outcome Measure for Age-Related Macular Degeneration.

ABSTRACT:

Purpose

To investigate the natural history of dark adaptation (DA) function as measured by the change in rod intercept time (RIT) over 4 years and to correlate RIT change with age-related macular degeneration (AMD) severity.

Design

Longitudinal, single-center, observational study.

Participants

A total of 77 participants aged ≥50 years with a range of AMD severities.

Methods

Participants each contributing a single study eye to the analysis were assigned into person-based AMD severity groups based on fundus characteristics (drusen, pigmentary changes, late AMD, and subretinal drusenoid deposits [SDDs]). The DA function was assessed in study eyes at baseline and 3, 6, 12, 18, 24, 36, and 48 months. Mean change in DA function over time was calculated using the slop

SUBMITTER: Chen KG 

PROVIDER: S-EPMC8380039 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature