Combinatorial Histone H3 Modifications Are Dynamically Altered in Distinct Cell Cycle Phases.

ABSTRACT: The cell cycle is a highly regulated and evolutionary conserved process that results in the duplication of cell content and the equal distribution of the duplicated chromosomes into a pair of daughter cells. Histones are fundamental structural components of chromatin in eukaryotic cells, and their post-translational modifications (PTMs) benchmark DNA readout and chromosome condensation. Aberrant regulation of the cell cycle associated with dysregulation of histone PTMs is the cause of critical diseases such as cancer. Monitoring changes of histone PTMs could pave the way to understanding the molecular mechanisms associated with epigenetic regulation of cell proliferation. Previously, our lab established a novel middle-down workflow using porous graphitic carbon (PGC) as a stationary phase

SUBMITTER: Lu C 

PROVIDER: S-EPMC8380055 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature