Decreased Spp1 Expression in Acute Myocardial Infarction after Ischemia and Reperfusion Injury.

ABSTRACT:

Background

With the progress of shock therapy and the establishment and promotion of methods such as thrombolytic therapy and percutaneous coronary intervention (PCI), many tissues and organs have been reperfused after ischemia which may cause even worse disorder called ischemia-reperfusion injury (IRI). mRNAs have been found to have significant impacts on ischemia-reperfusion through various mechanisms. In view of the accessibility of mRNAs from blood, we aimed to find the association between mRNA and ischemia-reperfusion.

Methods

We used the GSE83472 dataset from the Gene Expression Omnibus (GEO) database to find differential RNA expression between ischemia-reperfusion tissue and control samples. In addition, Gene Ontology (GO) annotation and Kyoto Encyclopedia of Genes an

SUBMITTER: Li L 

PROVIDER: S-EPMC8380156 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature