TMIGD1 Inhibited Abdominal Adhesion Formation by Alleviating Oxidative Stress in the Mitochondria of Peritoneal Mesothelial Cells.

ABSTRACT:

Background

Postoperative abdominal adhesion remains one of the frequent complications after abdominal surgery and lacks effective intervention. Peritoneal mesothelial cell injury and healing play crucial roles in the process of adhesion formation, and identifying this mechanism might provide new insight into possible new therapeutic strategies for this disease. Transmembrane and immunoglobulin domain-containing 1 (TMIGD1) has been proven to protect renal epithelial cells from injury induced by oxidative stress and has also been identified as a novel adhesion molecule. Here, we investigated the role of TMIGD1 and its possible mechanism in adhesion formation.

Materials and methods

Immunohistochemistry (IHC), qPCR, and immunofluorescence (IHF) were used to detect the expression

SUBMITTER: Wu Y 

PROVIDER: S-EPMC8380160 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature