Reactive Oxygen Species (ROS) Regulates Different Types of Cell Death by Acting as a Rheostat.

ABSTRACT: Reactive oxygen species (ROS) are essential for cellular signaling and response to stress. The level of ROS and the type of ROS determine the ability of cells to undergo cell death. Furthermore, dysregulation of the antioxidant pathways is associated with many diseases. It has become apparent that cell death can occur through different mechanisms leading to the classifications of different types of cell death such as apoptosis, ferroptosis, and necroptosis. ROS play essential roles in all forms of cell death, but it is only now coming into focus that ROS control and determine the type of cell death that occurs in any given cell. Indeed, ROS may act as a rheostat allowing different cell death mechanisms to be engaged and crosstalk with different cell death types. In this review, we will des

SUBMITTER: Villalpando-Rodriguez GE 

PROVIDER: S-EPMC8380163 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature