Association of toll-like receptor 4, 5 and 10 polymorphisms with Helicobacter pylori-positive peptic ulcer disease in a center in Jordan.

ABSTRACT:

Background

Helicobacter pylori infection is widespread, affecting about 50% of the global population. Polymorphisms in host genes such as the toll-like receptor 4 (TLR4) might affect the susceptibility and severity of infection and treatment success.

Objective

Investigate the susceptibility and severity of H pylori infection with host TLR4 (rs11536889, rs4986790, rs200109652, rs10759932), TLR5 (rs5744174, rs2072493, rs746250566), TLR10 (rs559182335, rs10004195) polymorphisms.

Design

Analytical, cross-sectional.

Setting

Endoscopy clinic at tertiary care center.

Patients and methods

Genomic DNA was extracted from formalin-fixed paraffin-embedded tissues collected from H pylori-infected patients and healthy i

SUBMITTER: Al-Eitan L 

PROVIDER: S-EPMC8380278 | biostudies-literature | 2021 Jul-Aug

REPOSITORIES: biostudies-literature