Identifying causal models between genetically regulated methylation patterns and gene expression in healthy colon tissue.

ABSTRACT:

Background

DNA methylation is involved in the regulation of gene expression and phenotypic variation, but the inter-relationship between genetic variation, DNA methylation and gene expression remains poorly understood. Here we combine the analysis of genetic variants related to methylation markers (methylation quantitative trait loci: mQTLs) and gene expression (expression quantitative trait loci: eQTLs) with methylation markers related to gene expression (expression quantitative trait methylation: eQTMs), to provide novel insights into the genetic/epigenetic architecture of colocalizing molecular markers.

Results

Normal mucosa from 100 patients with colon cancer and 50 healthy donors included in the Colonomics project have been analyzed. Linear models have been used to find

SUBMITTER: Diez-Villanueva A 

PROVIDER: S-EPMC8380335 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature