Sibling umbilical cord blood infusion is safe in young children with cerebral palsy.

ABSTRACT: Preclinical and early phase clinical studies suggest that an appropriately dosed umbilical cord blood (CB) infusion has the potential to help improve motor function in young children with cerebral palsy (CP). As many children with CP do not have their own CB available, use of allogeneic cells would extend access to this potentially beneficial therapy to more children. In this phase I, open-label study, 15 children, aged 1 to 6 years, with moderate to severe spastic CP were treated with a single intravenous infusion of allogeneic human leukocyte antigen (HLA) matched or partially matched sibling CB with a cell dose of ≥2.5 × 10⁷ cells/kg based on the pre-cryopreservation count (median infused cell dose, 3.3 × 10⁷ ; range, 1.8-5.2 × 10⁷ ). There were a total

SUBMITTER: Sun JM 

PROVIDER: S-EPMC8380440 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature