Dynamic Network Biomarker of Pre-Exhausted CD8⁺ T Cells Contributed to T Cell Exhaustion in Colorectal Cancer.

ABSTRACT: Immunotherapy has achieved positive clinical responses in various cancers. However, in advanced colorectal cancer (CRC), immunotherapy is challenging because of the deterioration of T-cell exhaustion, the mechanism of which is still unclear. In this study, we depicted CD8⁺ T-cell developmental trajectories and characterized the pre-exhausted T cells isolated from CRC patients in the scRNA-seq data set using a dynamic network biomarker (DNB). Moreover, CCT6A identified by DNB was a biomarker for pre-exhausted T-cell subpopulation in CRC. Besides, TUBA1B expression was triggered by CCT6A as DNB core genes contributing to CD8⁺ T cell exhaustion, indicating that core genes serve as biomarkers in pre-exhausted T cells. Remarkably, both TUBA1B an

SUBMITTER: Hu J 

PROVIDER: S-EPMC8381053 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature