Lung diffusing capacity for nitric oxide measured by two commercial devices: a randomised crossover comparison in healthy adults.

ABSTRACT: In Europe, two commercial devices are available to measure combined single-breath diffusing capacity of the lung for nitric oxide (D _LNO) and carbon monoxide (D _LCO) in one manoeuvre. Reference values were derived by pooling datasets from both devices, but agreement between devices has not been established. We conducted a randomised crossover trial in 35 healthy adults (age 40.0±15.5 years, 51% female) to compare D _LNO (primary end-point) between MasterScreen™ (Vyaire Medical, Mettawa, IL, USA) and HypAir (Medisoft, Dinant, Belgium) devices during a single visit under controlled conditions. Linear mixed models were used adjusting for device and period as fixed effects and random intercept for each participant. Difference in D

SUBMITTER: Radtke T 

PROVIDER: S-EPMC8381155 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature