Exploration of biomarkers from a pilot weight management study for men undergoing radical prostatectomy.

ABSTRACT:

Background

Several biologic mechanisms, including inflammation and immune changes, have been proposed to explain the role of obesity in prostate cancer (CaP) progression. Compared to men of a healthy weight, overweight and obese men are more likely to have CaP recurrence post-prostatectomy. Obesity is related to inflammation and immune dysregulation; thus, weight loss may be an avenue to reduce inflammation and reverse these immune processes.

Objectives

This study explores the reversibility of the biological mechanisms through intentional weight loss using a comprehensive weight management program in men undergoing prostatectomy. Outcomes include blood and tissue biomarkers, microtumor environment gene expression, inflammation markers and Dietary Inflammatory Index (DII) sco

SUBMITTER: Dimachkie MD 

PROVIDER: S-EPMC8381268 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature