The state of renal sympathetic denervation for the management of patients with hypertension: A systematic review and meta-analysis.

ABSTRACT:

Background

Sympathetic nervous system plays a central role in the development and persistence of essential hypertension. In recent years renal sympathetic denervation (RSD) has emerged as a promising option for the treatment of patients with hypertension.

Methods

We conducted a literature search of PubMed, EMBASE, Cochrane library and Clinicaltrials.gov from inception through April 20, 2020. Outcomes of interest were change in 24-hour ambulatory systolic (ASBP) or diastolic blood pressure (ADBP) and change in office systolic (OSBP) or diastolic blood pressure (ODBP). We pooled data from randomized controlled trials (RCTS) comparing RSD to sham procedures in the management of hypertension using the random effect model.

Results

A total of 1,363 patients from eight studi

SUBMITTER: Syed M 

PROVIDER: S-EPMC8381272 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature