The VNTR of the AS3MT gene is associated with brain activations during a memory span task and their training-induced plasticity.

ABSTRACT:

Background

The Arsenic (+3 oxidation state) methyltransferase (AS3MT) gene has been identified as a top risk gene for schizophrenia in several large-scale genome-wide association studies. A variable number tandem repeat (VNTR) of this gene is the most significant expression quantitative trait locus, but its role in brain activity in vivo is still unknown.

Methods

We first performed a functional magnetic resonance imaging (fMRI) scan of 101 healthy subjects during a memory span task, trained all subjects on an adaptive memory span task for 1 month, and finally performed another fMRI scan after the training. After excluding subjects with excessive head movements for one or more scanning sessions, data from 93 subjects were included in the final analyses.

Results

The VNT

SUBMITTER: Zhao W 

PROVIDER: S-EPMC8381288 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature