Evaluating the Causal Association Between Educational Attainment and Asthma Using a Mendelian Randomization Design.

ABSTRACT: Asthma is a common chronic respiratory disease. In the past 10 years, genome-wide association study (GWAS) has been widely used to identify the common asthma genetic variants. Importantly, these publicly available asthma GWAS datasets provide important data support to investigate the causal association of kinds of risk factors with asthma by a Mendelian randomization (MR) design. It is known that socioeconomic status is associated with asthma. However, it remains unclear about the causal association between socioeconomic status and asthma. Here, we selected 162 independent educational attainment genetic variants as the potential instruments to evaluate the causal association between educational attainment and asthma using large-scale GWAS datasets of educational attainment (n = 405,

SUBMITTER: Li Y 

PROVIDER: S-EPMC8381375 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature