Time to blood, respiratory and urine culture positivity in the intensive care unit: Implications for de-escalation.

ABSTRACT:

Objectives

Concern for late detection of bacterial pathogens is a barrier to early de-escalation efforts. The purpose of this study was to assess blood, respiratory and urine culture results at 72 h to test the hypothesis that early negative culture results have a clinically meaningful negative predictive value.

Methods

We retrospectively reviewed all patients admitted to the medical intensive care unit between March 2012 and July 2018 with blood cultures obtained. Blood, respiratory and urine culture results were assessed for time to positivity, defined as the time between culture collection and preliminary species identification. The primary outcome was the negative predictive value of negative blood culture results at 72 h. Secondary outcomes included sensitivity, specifi

SUBMITTER: Sellers LA 

PROVIDER: S-EPMC8381457 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature