Estimation of total mediation effect for high-dimensional omics mediators.

ABSTRACT:

Background

Environmental exposures can regulate intermediate molecular phenotypes, such as gene expression, by different mechanisms and thereby lead to various health outcomes. It is of significant scientific interest to unravel the role of potentially high-dimensional intermediate phenotypes in the relationship between environmental exposure and traits. Mediation analysis is an important tool for investigating such relationships. However, it has mainly focused on low-dimensional settings, and there is a lack of a good measure of the total mediation effect. Here, we extend an R-squared (R[Formula: see text]) effect size measure, originally proposed in the single-mediator setting, to the moderate- and high-dimensional mediator settings in the mixed model framework.

Results

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SUBMITTER: Yang T 

PROVIDER: S-EPMC8381496 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature