IGlioSub: an integrative transcriptomic and epigenomic classifier for glioblastoma molecular subtypes.

ABSTRACT:

Background

Glioblastoma (GBM) is the most aggressive and prevalent primary brain tumor, with a median survival of 15 months. Advancements in multi-omics profiling combined with computational algorithms have unraveled the existence of three GBM molecular subtypes (Classical, Mesenchymal, and Proneural) with clinical relevance. However, due to the costs of high-throughput profiling techniques, GBM molecular subtyping is not currently employed in clinical settings.

Methods

Using Random Forest and Nearest Shrunken Centroid algorithms, we constructed transcriptomic, epigenomic, and integrative GBM subtype-specific classifiers. We included gene expression and DNA methylation (DNAm) profiles from 304 GBM patients profiled in the Cancer Genome Atlas (TCGA), the Human Glioblastoma Ce

SUBMITTER: Ensenyat-Mendez M 

PROVIDER: S-EPMC8381510 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature