Antifibrotic effect of lung-resident progenitor cells with high aldehyde dehydrogenase activity.

ABSTRACT:

Background

Aldehyde dehydrogenase (ALDH) is highly expressed in stem/progenitor cells in various tissues, and cell populations with high ALDH activity (ALDH^br) are associated with tissue repair. However, little is known about lung-resident ALDH^br. This study was performed to clarify the characteristics of lung-resident ALDH^br cells and to evaluate their possible use as a tool for cell therapy using a mouse model of bleomycin-induced pulmonary fibrosis.

Methods

The characteristics of lung-resident/nonhematopoietic (CD45^-) ALDH^br cells were assessed in control C57BL/6 mice. The kinetics and the potential usage of CD45^-/ALDH^br for cell therapy were investigated in bleomycin-induced pulmonary fibrosis.

SUBMITTER: Takahashi H 

PROVIDER: S-EPMC8381511 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature