Epigenetic age is associated with baseline and 3-year change in frailty in the Canadian Longitudinal Study on Aging.

ABSTRACT:

Background

The trajectory of frailty in older adults is important to public health; therefore, markers that may help predict this and other important outcomes could be beneficial. Epigenetic clocks have been developed and are associated with various health-related outcomes and sociodemographic factors, but associations with frailty are poorly described. Further, it is uncertain whether newer generations of epigenetic clocks, trained on variables other than chronological age, would be more strongly associated with frailty than earlier developed clocks. Using data from the Canadian Longitudinal Study on Aging (CLSA), we tested the hypothesis that clocks trained on phenotypic markers of health or mortality (i.e., Dunedin PoAm, GrimAge, PhenoAge and Zhang in Nat Commun 8:14617, 2017) w

SUBMITTER: Verschoor CP 

PROVIDER: S-EPMC8381580 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature