Add-On Selective Estrogen Receptor Modulators for Methadone Maintenance Treatment.

ABSTRACT: Methadone maintenance treatment (MMT) remains the cornerstone for the management of opiate abuse. However, MMT can be associated with complex factors, including complications during the tolerance phase, the inability of some patients to maintain treatment effects during the tapering or abstinence phases, and the development of methadone dependence. Previous studies have revealed a sex disparity in MMT efficacy, showing that women undergoing MMT experiencing an increase in psychological symptoms compared with men and suggesting a link between disparate responses and the effects of estrogen signaling on methadone metabolism. More specifically, estradiol levels are positively associated with MMT dosing, and the expression of a single-nucleotide polymorphism (SNP) associated with estrogen rece

SUBMITTER: Huang CL 

PROVIDER: S-EPMC8381776 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature