Bifidobacterium animalis: the missing link for the cancer-preventive effect of Gynostemma pentaphyllum.

ABSTRACT: Colorectal cancer (CRC) ranks the third most common cancer type in both men and women. Besides the known genetic and epigenetic changes in the gut epithelial cells, we now know that disturbed gut microbes could also contribute to the onset and progression of CRC. Hence, keeping a balanced gut microbiota (GM) has become a novel pursue in the medical field, particularly in the area of gastrointestinal disorders. Gynostemma pentaphyllum (Gp) is a dietary herbal medicine. In our previous study, Gp saponins (GpS) displayed prebiotic and cancer-preventive properties through the modulation of GM in Apc^Min/+ mice. However, the specific group(s) of GM links to the health effects of GpS remains unknown. To track down the missing link, we first investigated and found that ino

SUBMITTER: Liao W 

PROVIDER: S-EPMC8381792 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature