An Effect of Education on Memory-Encoding Activation in Subjective Cognitive Decline.

ABSTRACT:

Background

Subjective cognitive decline (SCD) may be an early manifestation of pre-clinical Alzheimer's disease. Elevated amyloid-β (Aβ) is a correlate of SCD symptoms in some individuals. The underlying neural correlates of SCD symptoms and their association with Aβ is unknown. SCD is a heterogeneous condition, and cognitive reserve may explain individual differences in its neural correlates.

Objective

We investigated the association between brain activation during memory encoding and SCD symptoms, as well as with Aβ, among older individuals. We also tested the moderating role of education (an index of cognitive reserve) on the associations.

Methods

We measured brain activation during the "face-name" memory-encoding fMRI task and Aβ deposition with Pittsburgh Compoun

SUBMITTER: Mizuno A 

PROVIDER: S-EPMC8382028 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature