The tardigrade Hypsibius exemplaris  has the active mitochondrial alternative oxidase that could be studied at animal organismal level.

ABSTRACT: Mitochondrial alternative oxidase (AOX) is predicted to be present in mitochondria of several invertebrate taxa including tardigrades. Independently of the reason concerning the enzyme occurrence in animal mitochondria, expression of AOX in human mitochondria is regarded as a potential therapeutic strategy. Till now, relevant data were obtained due to heterologous AOX expression in cells and animals without natively expressed AOX. Application of animals natively expressing AOX could importantly contribute to the research. Thus, we decided to investigate AOX activity in intact specimens of the tardigrade Hypsibius exemplaris. We observed that H. exemplaris specimens' tolerance to the blockage of the mitochondrial respiratory chain (MRC) cytochrome pathway was diminished in the presence of A

SUBMITTER: Wojciechowska D 

PROVIDER: S-EPMC8382173 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature