A large-scale brain network mechanism for increased seizure propensity in Alzheimer's disease.

ABSTRACT: People with Alzheimer's disease (AD) are 6-10 times more likely to develop seizures than the healthy aging population. Leading hypotheses largely consider hyperexcitability of local cortical tissue as primarily responsible for increased seizure prevalence in AD. However, in the general population of people with epilepsy, large-scale brain network organization additionally plays a role in determining seizure likelihood and phenotype. Here, we propose that alterations to large-scale brain network organization seen in AD may contribute to increased seizure likelihood. To test this hypothesis, we combine computational modelling with electrophysiological data using an approach that has proved informative in clinical epilepsy cohorts without AD. EEG was recorded from 21 people with probable AD a

SUBMITTER: Tait L 

PROVIDER: S-EPMC8382184 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature