Exosomal miR-224 contributes to hemolymph microbiota homeostasis during bacterial infection in crustacean.

ABSTRACT: It is well known that exosomes could serve as anti-microbial immune factors in animals. However, despite growing evidences have shown that the homeostasis of the hemolymph microbiota was vital for immune regulation in crustaceans, the relationship between exosomes and hemolymph microbiota homeostasis during pathogenic bacteria infection has not been addressed. Here, we reported that exosomes released from Vibrio parahaemolyticus-infected mud crabs (Scylla paramamosain) could help to maintain the homeostasis of hemolymph microbiota and have a protective effect on the mortality of the host during the infection process. We further confirmed that miR-224 was densely packaged in these exosomes, resulting in the suppression of HSP70 and disruption of the HSP70-TRAF6 complex, then the released TR

SUBMITTER: Gong Y 

PROVIDER: S-EPMC8382196 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature