Heart rate mean and variability as a biomarker for phenotypic variation in preschoolers with autism spectrum disorder.

ABSTRACT: Interest in autonomic arousal in autism spectrum disorder (ASD) is increasing; however, reliability of these measures in ASD is unknown, and previously reported associations with social and cognitive abilities are inconsistent. This study assesses heart rate (HR) and HR variability (HRV) in preschoolers with ASD or typical development (TD) while they passively watched naturalistic videos. Measurement reliability, group differences, and the relationship with social and cognitive abilities were evaluated. Seventy one ASD and 66 TD children (2-4 years) provided cardiac data from two sessions. Test-retest intraclass correlations of HR and HRV over a 3-week period were moderate to good in both groups. Groups did not differ in mean level of HR or HRV. Intra-individual variability of HR between v

SUBMITTER: Bazelmans T 

PROVIDER: S-EPMC8382280 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature