An overview of potential inhibitors targeting non-structural proteins 3 (PL^pro and Mac1) and 5 (3CL^pro/M^pro) of SARS-CoV-2.

ABSTRACT: There is an urgent need to develop effective treatments for coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The rapid spread of SARS-CoV-2 has resulted in a global pandemic that has not only affected the daily lives of individuals but also had a significant impact on the global economy and public health. Although extensive research has been conducted to identify inhibitors targeting SARS-CoV-2, there are still no effective treatment strategies to combat COVID-19. SARS-CoV-2 comprises two important proteolytic enzymes, namely, the papain-like proteinase, located within non-structural protein 3 (nsp3), and nsp5, both of which cleave large replicase polypeptides into multiple fragments that are required for viral replicatio

SUBMITTER: Yan F 

PROVIDER: S-EPMC8382591 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature