Replication and cross-validation of type 2 diabetes subtypes based on clinical variables: an IMI-RHAPSODY study.

ABSTRACT:

Aims/hypothesis

Five clusters based on clinical characteristics have been suggested as diabetes subtypes: one autoimmune and four subtypes of type 2 diabetes. In the current study we replicate and cross-validate these type 2 diabetes clusters in three large cohorts using variables readily measured in the clinic.

Methods

In three independent cohorts, in total 15,940 individuals were clustered based on age, BMI, HbA_1c, random or fasting C-peptide, and HDL-cholesterol. Clusters were cross-validated against the original clusters based on HOMA measures. In addition, between cohorts, clusters were cross-validated by re-assigning people based on each cohort's cluster centres. Finally, we compared the time to insulin requirement for each cluster.

Results

Five disti

SUBMITTER: Slieker RC 

PROVIDER: S-EPMC8382625 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature