Development and validation of a cardiovascular risk prediction model in type 1 diabetes.

ABSTRACT:

Aims/hypothesis

We aimed to report current rates of CVD in type 1 diabetes and to develop a CVD risk prediction tool for type 1 diabetes.

Methods

A cohort of 27,527 people with type 1 diabetes without prior CVD was derived from the national register in Scotland. Incident CVD events during 199,552 person-years of follow-up were ascertained using hospital admissions and death registers. A Poisson regression model of CVD was developed and then validated in the Swedish National Diabetes Register (n = 33,183). We compared the percentage with a high 10 year CVD risk (i.e., ≥10%) using the model with the percentage eligible for statins using current guidelines by age.

Results

The age-standardised rate of CVD per 100,000 person-years was 4070 and 3429 in men and women, respec

SUBMITTER: McGurnaghan SJ 

PROVIDER: S-EPMC8382639 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature