Perturbations in cardiac metabolism in a human model of acute myocardial ischaemia.

ABSTRACT:

Introduction

Acute myocardial ischaemia and the transition from reversible to irreversible myocardial injury are associated with abnormal metabolic patterns. Advances in metabolomics have extended our capabilities to define these metabolic perturbations on a metabolome-wide scale.

Objectives

This study was designed to identify cardiac metabolic changes in serum during the first 5 min following early myocardial ischaemia in humans, applying an untargeted metabolomics approach.

Methods

Peripheral venous samples were collected from 46 patients in a discovery study (DS) and a validation study (VS) (25 for DS, 21 for VS). Coronary sinus venous samples were collected from 7 patients (4 for DS, 3 for VS). Acute myocardial ischaemia was induced by transient coronary occlusion

SUBMITTER: Chacko S 

PROVIDER: S-EPMC8382649 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature