Non-alcoholic fatty liver disease in mice with hepatocyte-specific deletion of mitochondrial fission factor.

ABSTRACT:

Aims/hypothesis

Mitochondria are highly dynamic organelles continuously undergoing fission and fusion, referred to as mitochondrial dynamics, to adapt to nutritional demands. Evidence suggests that impaired mitochondrial dynamics leads to metabolic abnormalities such as non-alcoholic steatohepatitis (NASH) phenotypes. However, how mitochondrial dynamics are involved in the development of NASH is poorly understood. This study aimed to elucidate the role of mitochondrial fission factor (MFF) in the development of NASH.

Methods

We created mice with hepatocyte-specific deletion of MFF (MffLiKO). MffLiKO mice fed normal chow diet (NCD) or high-fat diet (HFD) were evaluated for metabolic variables and their livers were examined by histological analysis. To elucidate the mechanism

SUBMITTER: Takeichi Y 

PROVIDER: S-EPMC8382662 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature