Thrombocytopenia after meta-iodobenzylguanidine (MIBG) therapy in neuroblastoma patients may be caused by selective MIBG uptake via the serotonin transporter located on megakaryocytes.

ABSTRACT:

Background

The therapeutic use of [¹³¹I]meta-iodobenzylguanidine ([¹³¹I]MIBG) is often accompanied by hematological toxicity, primarily consisting of severe and persistent thrombocytopenia. We hypothesize that this is caused by selective uptake of MIBG via the serotonin transporter (SERT) located on platelets and megakaryocytes. In this study, we have investigated whether in vitro cultured human megakaryocytes are capable of selective plasma membrane transport of MIBG and whether pharmacological intervention with selective serotonin reuptake inhibitors (SSRIs) may prevent this radiotoxic MIBG uptake.

Methods

Peripheral blood CD34⁺ cells were differentiated to human megakaryocytic cells using a standardized culture protocol. Prior to [^3</

SUBMITTER: Blom T 

PROVIDER: S-EPMC8382772 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature