Bidirectional Correlations Between Dopaminergic Function and Motivation in Parkinson's Disease.

ABSTRACT:

Objective

To test the hypothesis that striatal dopamine function influences motivational alterations in Parkinson disease (PD), we compared vesicular monoamine transporter 2 (VMAT2) and dopamine transporter (DaT) imaging data in PD patients with impulse control disorders (ICDs), apathy, or neither.

Methods

We extracted striatal binding ratios (SBR) from VMAT2 PET imaging (¹⁸F-AV133) and DaTscans from the Parkinson's Progression Markers Initiative (PPMI) multicenter observational study. Apathy and ICDs were assessed using the Movement Disorders Society-revised Unified Parkinson's Disease Rating Scale (MDS-UPDRS) and the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease (QUIP), respectively. We used analysis of variance (ANOVA) and log-linear m

SUBMITTER: Hinkle JT 

PROVIDER: S-EPMC8382801 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature