Pulmonary immune cell trafficking promotes host defense against alcohol-associated Klebsiella pneumonia.

ABSTRACT: The intestinal microbiota generates many different metabolites which are critical for the regulation of host signaling pathways. In fact, a wide-range of diseases are associated with increased levels of local or systemic microbe-derived metabolites. In contrast, certain bacterial metabolites, such as tryptophan metabolites, are known to contribute to both local and systemic homeostasis. Chronic alcohol consumption is accompanied by alterations to intestinal microbial communities, and their functional capacities. However, little is known about the role of alcohol-associated dysbiosis on host defense against bacterial pneumonia. Our previous work using fecal transplantation demonstrated that alcohol-associated intestinal dysbiosis, independent of ethanol consumption, increased susceptibility

SUBMITTER: Samuelson DR 

PROVIDER: S-EPMC8382828 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature