Bacterial Evolutionary Precursors of Eukaryotic Copper-Zinc Superoxide Dismutases.

ABSTRACT: Internalization of a bacteria by an archaeal cell expedited eukaryotic evolution. An important feature of the species that diversified into the great variety of eukaryotic life visible today was the ability to combat oxidative stress with a copper-zinc superoxide dismutase (CuZnSOD) enzyme activated by a specific, high-affinity copper chaperone. Adoption of a single protein interface that facilitates homodimerization and heterodimerization was essential; however, its evolution has been difficult to rationalize given the structural differences between bacterial and eukaryotic enzymes. In contrast, no consistent strategy for the maturation of periplasmic bacterial CuZnSODs has emerged. Here, 34 CuZnSODs are described that closely resemble the eukaryotic form but originate predominantly from

SUBMITTER: Wright GSA 

PROVIDER: S-EPMC8382915 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature