Diagnostic Performance of ¹⁸F-DCFPyL-PET/CT in Men with Biochemically Recurrent Prostate Cancer: Results from the CONDOR Phase III, Multicenter Study.

ABSTRACT:

Purpose

Current FDA-approved imaging modalities are inadequate for localizing prostate cancer biochemical recurrence (BCR). ¹⁸F-DCFPyL is a highly selective, small-molecule prostate-specific membrane antigen-targeted PET radiotracer. CONDOR was a prospective study designed to determine the performance of ¹⁸F-DCFPyL-PET/CT in patients with BCR and uninformative standard imaging.

Experimental design

Men with rising PSA ≥0.2 ng/mL after prostatectomy or ≥2 ng/mL above nadir after radiotherapy were eligible. The primary endpoint was correct localization rate (CLR), defined as positive predictive value with an additional requirement of anatomic lesion colocalization between ¹⁸F-DCFPyL-PET/CT and a composite standard of truth (SOT). The SOT consist

SUBMITTER: Morris MJ 

PROVIDER: S-EPMC8382991 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature