Metabolic engineering of Synechocystis sp. PCC 6803 for the photoproduction of the sesquiterpene valencene.

ABSTRACT: Cyanobacteria are extremely adaptable, fast-growing, solar-powered cell factories that, like plants, are able to convert carbon dioxide into sugar and oxygen and thereby produce a large number of important compounds. Due to their unique phototrophy-associated physiological properties, i.e. naturally occurring isoprenoid metabolic pathway, they represent a highly promising platform for terpenoid biosynthesis. Here, we implemented a carefully devised engineering strategy to boost the biosynthesis of commercially attractive plant sequiterpenes, in particular valencene. Sesquiterpenes are a diverse group of bioactive metabolites, mainly produced in higher plants, but with often low concentrations and expensive downstream extraction. In this work we successfully demonstrate a multi-component en

SUBMITTER: Dietsch M 

PROVIDER: S-EPMC8382996 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature