Erastin‑induced ferroptosis causes physiological and pathological changes in healthy tissues of mice.

ABSTRACT: Ferroptosis is a non‑apoptotic form of cell death that relies on iron and lipid peroxidation, which is associated with multiple pathological processes in several diseases. Erastin is a small molecule capable of initiating ferroptotic cell death in cancer cells, which has shown great potential for cancer therapy. However, the physiological and pathological role of erastin‑induced ferroptosis on healthy tissues has not been well characterized. The present study intraperitoneally injected erastin into healthy mice to detect the metabolic changes of several tissues of mice. Erastin injection induced typical characteristics of ferroptosis with higher level of serum iron and malondialdehyde and lower level of glutathione and glutathione peroxidase 4 protein. Erastin injection enhanced iron depos

SUBMITTER: Zhao J 

PROVIDER: S-EPMC8383038 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature