The molecular feature of macrophages in tumor immune microenvironment of glioma patients.

ABSTRACT:

Background

Gliomas are one of the most common types of primary tumors in central nervous system. Previous studies have found that macrophages actively participate in tumor growth.

Methods

Weighted gene co-expression network analysis was used to identify meaningful macrophage-related gene genes for clustering. Pamr, SVM, and neural network were applied for validating clustering results. Somatic mutation and methylation were used for defining the features of identified clusters. Differentially expressed genes (DEGs) between the stratified groups after performing elastic regression and principal component analyses were used for the construction of MScores. The expression of macrophage-specific genes were evaluated in tumor microenvironment based on single cell sequencing analys

SUBMITTER: Zhang H 

PROVIDER: S-EPMC8383063 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature