Targeted Immunotherapies in Gastrointestinal Cancer: From Molecular Mechanisms to Implications.

ABSTRACT: Gastrointestinal cancer is a leading cause of cancer-related mortality and remains a major challenge for cancer treatment. Despite the combined administration of modern surgical techniques and chemoradiotherapy (CRT), the overall 5-year survival rate of gastrointestinal cancer patients in advanced stage disease is less than 15%, due to rapid disease progression, metastasis, and CRT resistance. A better understanding of the mechanisms underlying cancer progression and optimized treatment strategies for gastrointestinal cancer are urgently needed. With increasing evidence highlighting the protective role of immune responses in cancer initiation and progression, immunotherapy has become a hot research topic in the integrative management of gastrointestinal cancer. Here, an overview of the mol

SUBMITTER: Wang DK 

PROVIDER: S-EPMC8383067 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature